famSKATRC - Family Sequence Kernel Association Test for Rare and Common
Variants
FamSKAT-RC is a family-based association kernel test for
both rare and common variants. This test is general and several
special cases are known as other methods: famSKAT, which only
focuses on rare variants in family-based data, SKAT, which
focuses on rare variants in population-based data (unrelated
individuals), and SKAT-RC, which focuses on both rare and
common variants in population-based data. When one applies
famSKAT-RC and sets the value of phi to 1, famSKAT-RC becomes
famSKAT. When one applies famSKAT-RC and set the value of phi
to 1 and the kinship matrix to the identity matrix, famSKAT-RC
becomes SKAT. When one applies famSKAT-RC and set the kinship
matrix (fullkins) to the identity matrix (and phi is not equal
to 1), famSKAT-RC becomes SKAT-RC. We also include a small
sample synthetic pedigree to demonstrate the method with. For
more details see Saad M and Wijsman EM (2014)
<doi:10.1002/gepi.21844>.